CORDIS Project
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This project focuses on understanding the regulation of a specific lipid kinase, phosphoinositide 3-kinase beta, which plays a crucial role in various diseases. By determining its structure and interactions, the research aims to inform the design of targeted therapies.
Many signaling pathways in human cells involve lipid recognition events.
The phosphorylation state of these lipids is under the control of both lipid kinases and lipid phosphatases.
The phosphorylated second messenger lipids recruit lipid adaptor molecules, which regulate fundamental cellular processes including cell survival, proliferation, motility, differentiation and intracellular trafficking.
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3’ hydroxyl…
MEDICAL RESEARCH COUNCIL
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