CORDIS Project
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This project investigates the diverse behaviors of endothelial cells within blood vessels, aiming to redefine our understanding of vascular function. By studying these behaviors in various models, it seeks to improve therapies targeting specific endothelial cell subsets.
Endothelial cells (ECs) form a dynamic monolayer lining the lumen of vessels.
While single-cell data have revealed high degrees of heterogeneity amongst ECs at the inter- and intra-organ levels, the prevailing notion has long been that vessels themselves are composed of largely similar ECs.
Instead, data from our labs challenge this view by showing that vessels are built of highly diverse ECs displaying different behavioral properties, a feature we term intravessel EC behavioral mosaicism.
Whil…
INSTITUT JOSEP CARRERAS - CERCA
FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS
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Israel, Rehovot
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
United States, New Haven
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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