CORDIS Project
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This project investigates the role of T follicular helper cells in the development of autoreactive B-cell responses in a murine model of autoimmune disease. It aims to understand how these cells contribute to the maturation and epitope spreading of autoreactive B-cells, which may inform potential therapeutic strategies…
The detection of autoantibodies typically appear a few years prior to clinical autoimmune disease and their reactivity can drift at or after disease onset.
The laboratory of M.C.
Carroll (outgoing institute) has developed a murine model (ARTEMIS;
Autoreactive B-cell driven T-dependent Epitope Migration towards Immunity to Self) where the presence of a single autoreactive B cell clone drives activation, expansion and differentiation of other autoreactive B-cells in spontaneous germinal centers (G…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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