CORDIS Project
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The BEAT project aims to understand the mechanisms behind dependency on the EGF receptor in colorectal cancer. By investigating genetic variations and their impact on treatment resistance, it seeks to identify biomarkers for better clinical management and develop new therapies to combat minimal residual disease.
Monoclonal antibodies against the EGF receptor (EGFR) provide substantive benefit to colorectal cancer (CRC) patients.
However, no genetic lesions that robustly predict ‘addiction’ to the EGFR pathway have been yet identified.
Further, even in tumours that regress after EGFR blockade, subsets of drug-tolerant cells often linger and foster ‘minimal residual disease’ (MRD), which portends tumour relapse.
Our preliminary evidence suggests that reliance on EGFR activity, as opposed to MRD persistenc…
UNIVERSITA DEGLI STUDI DI TORINO
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