CORDIS Project
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This project investigates how mutations in the FOXO1 gene affect B-cell lymphomas, particularly in the absence of B-Cell Receptor signaling. By using mouse and human models, it aims to understand the role of these mutations in enhancing cell survival and fitness in cancerous B cells.
Loss of B-Cell Receptor (BCR) in lymphoma B cells leads to attenuated PI3K/AKT signaling and altered Myc-dependent transcriptional output, resulting in a competitive disadvantage in BCR-deficient lymphoma cells.
The acquisition of genetic events restoring signaling competence is sufficient to improve cellular fitness in BCR-deficient lymphomas. A fraction of Non-Hodgkin-B-cell lymphomas carry missense mutations in FOXO1, a transcription factor essential during B cell development, and a main targ…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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Italy, Ferrara
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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