CORDIS Project
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This project investigates the role of the ubiquitin proteasome system in B-cell malignancies, focusing on genomic instability. It aims to identify new therapeutic targets and biomarkers by studying orphan ubiquitin ligases and deubiquitylating enzymes in multiple myeloma and mantle cell lymphoma.
B-cell malignancies are characterized by high levels of genomic instability, which critically contribute to their pathogenesis and evolution.
Recently, the fundamental role of the ubiquitin proteasome system (UPS) in maintaining genome integrity has been appreciated.
Two major new therapeutic modalities in B-cell malignancies, proteasome inhibitors and imunomodulatory drugs (IMiDs), target the UPS and demonstrate particular efficacy in multiple myeloma (MM) and mantle cell lymphoma (MCL), two in…
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