CORDIS Project
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This project investigates the molecular mechanisms behind B cell lymphomas, focusing on the role of Activation Induced Deaminase in chromosome translocations. It aims to understand how these processes contribute to lymphomagenesis and the balance between B cell proliferation and death.
Most of the lymphomas diagnosed in the western world are originated from mature B cells.
The hallmark of these malignancies is the presence of recurrent chromosome translocations that usually involve the immunoglobulin loci and a proto-oncogene.
As a result of the translocation event the proto-oncogene becomes deregulated under the influence of immunoglobulin cis sequences thus playing an important role in the etiology of the disease.
Upon antigen encounter mature B cells engage in the germinal…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain, Madrid
Type: Research institute
Activity type: Research Organisations
SME: No
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