CORDIS Project
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This project investigates the cooperation between c-Jun and BCL6 in the development of lymphoma. By using transgenic mouse models and various biochemical techniques, it aims to understand how these oncogenes interact and contribute to tumor progression, ultimately informing potential anti-cancer therapies.
Sequential activation of different oncogenes drive the step-wise progression of precancerous cells to highly malignant tumors. A molecular understanding of the transformation events is crucial to develop anti-cancer therapies.
In this sense, The AP-1 transcription factor has gained special attention in the last decades due to its key role in the tumor development. AP-1 comprises a family of dimeric basic region-leucine zipper transcription factors.
The founding members of the AP-1 family, c-Fos…
CANCER RESEARCH UK LBG
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