CORDIS Project
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This research investigates the immune response of bats to coronaviruses, focusing on cytokine secretion mechanisms. By comparing human and bat cells, the project aims to uncover why bats tolerate these infections, potentially informing new antiviral strategies against emerging zoonotic viruses.
The majority of coronaviruses (CoV) originally emerged from bats including highly pathogenic SARS- and MERS-CoV.
Bats evolved unique innate immune mechanisms that are likely responsible for the lack of immune pathology.
One key process of the immune response is the secretion of cytokines, like interleukins (IL) and type I interferons (IFNs), however molecular details of cytokine secretions and their influence on the outcome of virus infections have not been studied in context of reservoir host s…
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