CORDIS Project
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The BATOFF project investigates how brown adipose tissue regulates heat production and energy expenditure in mammals. By exploring the molecular mechanisms that control this thermogenic organ, the project aims to uncover potential therapeutic strategies for obesity and diabetes management.
Free-ranging animals are continuously exposed to fluctuating ambient temperature, therefore rapid fine-tuning of thermogenesis to maintain core temperature homeostasis is critical for survival.
Brown adipose tissue (BAT) evolves as a thermogenic organ, the rapid switching on and off is essential for thermal regulation.
Of note, thermogenesis inevitably comes at high energetic cost and BAT ultimately is an energy-wasting organ. A constrained strategy that minimizes BAT activity unless obligate wi…
UNIVERSITATSKLINIKUM BONN
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