CORDIS Project
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This project investigates how T cells process signals from various receptors to make decisions in immune responses. By employing advanced proteomics techniques, it aims to decode the interactions between T cell receptors and their signaling partners, which could enhance understanding of immune system functioning.
Although the T cell antigen receptor (TCR) occupies a central place in T cell physiology, it does not work in isolation and the signals it triggers are tuned by receptors that convey positive (costimulators) and negative (coinhibitors) informations.
We lack a satisfying comprehension of the way T cells integrate such multiple inputs to make informed decisions.
The proteomics-based methodology we developed around the TCR places us in a favorable situation to decode at systems-level the crosstalk…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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