CORDIS Project
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This research focuses on the biosynthesis of curli, functional amyloid fibers in bacteria, particularly Escherichia coli. It aims to understand the molecular mechanisms of curli formation and transport, with potential applications in biotechnology for creating functional nanostructures.
Curli are functional amyloid fibers that constitute the major protein component of the extracellular matrix in pellicle biofilms formed by Bacteroidetes and Proteobacteria.
Unlike the protein misfolding and aggregation events seen in pathological amyloid diseases such as Alzheimer’s and Parkinson’s disease, curli are the product of a dedicated protein secretion machinery.
Curli formation requires a specialised and mechanistically unique transporter in the bacterial outer membrane, as well as tw…
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