CORDIS Project
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This project investigates how E. coli bacteria respond to combined stresses of heat and antibiotics at a single-cell level. By using microfluidics and advanced imaging techniques, it aims to understand the role of heat shock proteins in bacterial survival and antibiotic resistance.
Antibiotic resistance is one of the biggest scientific and health challenges of our time.
If actions are not taken, antibiotics resistance infections will become the first cause of death by 2050.
One of the most common signs of bacterial infection is a rapid increase of the host temperature that exposes bacteria to a heat shock (HS).
To survive and quickly adapt to this new environment, bacteria activate the synthesis of specific proteins, called heat shock proteins (HSPs).
In E.coli, HSPs expre…
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