CORDIS Project
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This research focuses on understanding the structure-function relationships of antimicrobial peptides to develop new compounds targeting bacterial resistance. It aims to investigate how peptide interactions with lipid membranes influence toxicity and antimicrobial activity.
Development of resistance by bacteria to antibiotics makes design of novel antimicrobial compounds increasingly important.
As persistent cells often become slow-growing or dormant, strategies targeting their membrane are becoming more relevant.
For several natural antimicrobial peptides function can be coupled to scaffolds with high sheet content.
Toxic oligomers may assemble into hydrophilic or lipophilic sheet rich barrel constructs.
However, this mechanism is not understood, greatly hindering…
HUN-REN RESEARCH CENTRE FOR NATURAL SCIENCES
HUN-REN TERMESZETTUDOMANYI KUTATOKOZPONT
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