CORDIS Project
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This project develops a non-invasive DNA-based barcoding system to study hematopoietic stem cells in their natural environment. It aims to uncover the developmental pathways of these cells and their role in the immune system.
The immune system is a complex ensemble of diverse lineages.
Studies on in-vivo-hematopoiesis have untilnow largely rested on transplantation.
More physiological experiments have been limited by the inability toanalyze hematopoietic stem (HSC) and progenitor cells in situ without cell isolation and other disruptivemanipulations.
We have developed mouse mutants in which a fluorescent marker can be switched on in HSCin situ (inducible fate mapping), and traced HSC lineage output under unperturbed…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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