CORDIS Project
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This project focuses on developing a novel sensing technology using designed peptide barrels that can detect various analytes. By addressing technical challenges, it aims to create a platform for array-based sensing that leverages the unique properties of these peptides.
In array-based sensing, synthetic receptors are appended with chromophores (reporters) and arrayed in various formats.
The arrays are treated with analytes that displace the reporter to different extents and the outputs are interpreted by computers to identify the analyte.
This has not been demonstrated for arrays of structured de novo designed peptides, which have many advantages over the synthetic small molecules currently used.
Through an ERC Advanced Grant, ABEL (340764), we have designed pe…
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