CORDIS Project
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This project investigates how outer membrane proteins are assembled in Bacteroidota bacteria, which are significant human commensals and pathogens. It focuses on understanding the unique mechanisms of protein biogenesis and the role of novel components in this process using various biochemical and genetic techniques.
Gram-negative bacteria are distinguished by the presence of an outer membrane (OM) at the cell periphery.
This membrane is the site at which the bacterium interacts with its environment (or host if a pathogen), and provides the first line of defence against antibiotics, mechanical stresses, and immunological attacks.
These functions depend on the presence of proteins that either span the outer membrane (Outer Membrane Proteins, or OMPs) or are anchored to the membrane by a lipid tail (lipoprotei…
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