CORDIS Project
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This project investigates the behavior of the Listeria monocytogenes bacterium and its integrated prophage, focusing on how the prophage regulates its late lytic genes during infection. The goal is to understand the molecular mechanisms of active-lysogeny, which could inform the development of phage therapy against bac…
Listeria monocytogenes (Lm) is an intracellular bacterial pathogen.
Lm strain 10403S harbors an active prophage in its genome integrated within the comK gene.
It was previously discovered by the Herskovits lab (host lab) that during Lm infection of macrophages, the prophage undergoes excision from comK, yielding an intact and functional comK gene that assists the escape of the bacteria from the macrophages’ phagosomes to the cytosol.
Notably, this phage excision does not lead to virion productio…
TEL AVIV UNIVERSITY
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