CORDIS Project
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The Bac2MUC project investigates how intestinal bacteria interact with transmembrane mucins, which play a key role in maintaining the epithelial barrier. The project aims to identify bacterial species that affect mucin functions and to elucidate the signaling pathways involved in inflammation and bacterial invasion.
The intestinal microbiota consists of beneficial commensal bacteria and pathobionts that cause inflammation.
The intestinal mucus layer dictates how specific members of the microbiota affect health and disease.
The mucus layer consists of soluble mucins and epithelial transmembrane (TM) mucins that regulate host responses.
The molecular mechanisms as to how the intestinal microbiota affect the functions of TM mucins is largely unknown.
My recent work shows that TM mucin MUC1 is a key receptor fo…
UNIVERSITEIT UTRECHT
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