CORDIS Project
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This project focuses on developing methods to synthesize borylated azines for use in the Suzuki-Miyaura cross-coupling reaction, a key process in pharmaceuticals. It aims to create stable borylated azines efficiently, facilitating their application in drug discovery and agrochemical production.
'The Nobel prize-winning Suzuki-Miyaura cross-coupling involves the palladium-catalysedcoupling of a borylated molecule with an aryl halide and is the 2nd most used process by thepharmaceutical sector.Azines are small-molecules integral to discover and manufacture pharmaceuticals andagrochemicals.
Using azines in Suzuki-Miyaura cross-coupling reactions represents the idealsolution to introduce these important motifs in discovery molecules but here is where theproblems come:1.
There is currently…
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
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