CORDIS Project
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This project explores the regulation of plasma cell differentiation in the immune system, focusing on the role of RNA-binding proteins in B cell development. It aims to understand how these proteins influence the fate of B cells during immune responses.
Plasma cells (PC) secreting high-affinity antibodies are key for long-term immunity and the success of vaccines. PC are mainly generated within the germinal centre (GC), a microenvironment where B cells undergo affinity maturation and selection.
The GC reaction guarantees that only B cells expressing immunoglobulin with the highest affinity for the antigen will commit to terminal differentiation.
Stringent regulation is essential, as dysfunctional GC B cells can cause defective immunity, autoimm…
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