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The BREAKING BAD project investigates how thymic B cells regulate the immune response to autoantigens associated with central nervous system diseases, such as Multiple Sclerosis and Alzheimer's disease. By manipulating thymic tolerance mechanisms, the project aims to enhance understanding of autoimmune disorders and de…
Failure of thymic tolerance may result in severe autoimmune diseases that target the central nervous system (CNS), including Multiple Sclerosis (MS), Myelin Oligodendrocyte Glycoprotein (MOG)-associated Disease (MOGAD), and Neuromyelitis Optica Spectrum Disorders (NMOSD).
Recently, we discovered a new layer of thymic tolerance in that thymic B cells get licensed to present activation-induced autoantigens, among them AQP4 (the target antigen in NMOSD).
Thymic B cells are necessary and sufficient…
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
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