CORDIS Project
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This project aims to map genome-wide interactions between regulatory elements during early B-cell development. By understanding how these elements influence gene regulation, the project seeks to create transcriptional networks that clarify the mechanisms driving B-cell differentiation.
A major challenge of modern cell biology is to understand how elaborate transcriptional programs drive developmental processes and maintain cellular identity.
In mammals temporal and cell type specific gene regulation depend on regulatory elements in the genome.
Genome-wide mapping studies have lead to the identification of myriads of regulatory elements.
Strikingly these elements not only exist in abundance compared to genes in the genome, but they are also preferentially located distal to tran…
KAROLINSKA INSTITUTET
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