CORDIS Project
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This project investigates how polyglutamylation, a modification of tubulin, influences microtubule functions in neurons, particularly in cargo transport. Using advanced microscopy and genetic techniques, it aims to clarify the relationship between this modification and neuronal health, contributing to our understanding…
The microtubule cytoskeleton plays crucial roles in regulating a vast range of biological processes in different cell types, in particular in neurons that strongly depend on intracellular transport for cargo delivery over long distances.
Posttranslational modifications (PTMs) of tubulin recently emerged as modulators of microtubule properties and functions, which is expected to dynamically adapt them to specific cellular functions.
Neuronal microtubules are strongly enriched in the PTM polygluta…
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