CORDIS Project
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This project aims to map the retrograde transport mechanisms in neurons, which are essential for long-distance communication in the nervous system. By utilizing advanced purification techniques, it seeks to identify the components involved in transporting neurotrophins and their signaling pathways.
The polarisation of neurons in somatodendritic and axonal compartments allows signal propagation over long distances.
Despite the important role played by electrical signals, fast axonal transport is crucial for long-range communication between the soma and distal synapses, which is carried out by vesicular transport mechanisms.
Neurotrophins and their receptors are internalised at axon terminals by clathrin-mediated endocytosis and conveyed by signalling endosomes to the soma, where they activa…
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