CORDIS Project
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This project examines the plasticity of myelinated axons in the brain, focusing on how changes in myelin and axonal properties affect nerve signal conduction. It aims to uncover the cellular mechanisms that enable these adaptations and their implications for information processing in the central nervous system.
The brain is divided into grey matter “processing nodes” linked by white matter “information superhighways” to minimize conduction delays and energy use.
For the white matter, the information propagation speed is increased and the axonal energy cost is reduced by oligodendrocytes wrapping myelin around axons, thus decreasing their capacitance and decreasing the Na+ influx needed at Ranvier nodes to produce an action potential.
This arrangement may not just speed action potentials, however, it ma…
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