CORDIS Project
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This project investigates the role of oligodendrocytes and Schwann cells in maintaining neuronal integrity, focusing on their interactions with axons. By studying these mechanisms in mice, the research aims to uncover how these glial cells support axonal health and may lead to new treatments for neurodegenerative disea…
In the human brain, the 'bottleneck' of neuronal integrity are long axonal projections, which are often the first to degenerate in neuro-psychiatric diseases.
We have discovered in mice that oligodendrocytes and Schwann cells are not only essential for the formation of myelin, but also for the functional integrity of axons and their long-term survival.
However, the underlying molecular mechanisms have remained obscure.
We propose to use experimental mouse genetics to study neuron-glia interactio…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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