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The AXLR8 project aims to modernize toxicity testing and risk assessment by developing a mechanistic understanding of how chemical exposures lead to health effects. It focuses on enhancing communication among researchers, streamlining regulatory processes, and creating a roadmap for future research in this field.
Conventional approaches to toxicity testing and risk assessment are often decades old, costly and low-throughput, and of dubious relevance to humans.
These factors have prompted leading scientific bodies to call for a transition to a 21st century paradigm, including a move away from apical outcomes at high doses in whole animals, and toward a mechanistic understanding of the source-to-outcome continuum between xenobiotic exposure and adverse health effects.
Such a shift will require a robust und…
FREIE UNIVERSITAET BERLIN
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