CORDIS Project
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This project investigates the structural interactions of the PB2 subunit of the avian influenza virus with human proteins that facilitate its replication. By employing advanced structural biology techniques, it aims to enhance understanding of viral mechanisms and inform drug design.
Due to its high prevalence among birds and high human fatality rate, avian influenza represents a serious and continuing pandemic threat, in particular via mutations that facilitate human infection, resulting in pathogenic strains.
Mutations associated with human infection are concentrated in the PB2 subunit of influenza polymerase.
This subunit is imported into the nucleus, where viral replication and transcription occurs, via a selective interaction with host importin-alpha proteins.
Once in t…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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