CORDIS Project
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This project focuses on understanding the molecular mechanisms of ubiquitin receptors, specifically their auto-inhibitory conformation. By developing a bacterial system for producing ubiquitylated proteins, the project aims to determine the structures of these receptors and their functional implications in diseases lik…
The cell interprets the information conferred by ubiquitin (Ub) through Ub-receptors, proteins that harbor ubiquitin-binding domains (UBDs).
Ub-receptors can be found in three mutually exclusive forms.
Apo is the unbound form, whereas trans is the intermolecular form bound to ubiquitylated cargo.
Intriguingly, the third form, cis, is of Ub-receptors that are themselves ubiquitylated.
Monoubiquitylation of the Ub-receptors imposes an auto-inhibitory conformation, rendering them unable to bind ubi…
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