CORDIS Project
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This project investigates the generation of autoantibodies in coeliac disease, focusing on the role of transglutaminase 2 and gluten-reactive T cells. It aims to understand the mechanisms behind B cell activation and antibody production in affected individuals.
The goal of this project is to understand the mechanism of how highly disease specific autoantibodies are generated in response to the exposure to a foreign antigen.
IgA autoantibodies reactive with the enzyme transglutaminase 2 (TG2) are typical of coeliac disease (CD).
These antibodies are only present in subjects who are HLA-DQ2 or -DQ8, and their production is dependent on dietary gluten exposure.
This suggests that CD4+ gluten reactive T cells, which are found in CD patients and which reco…
UNIVERSITETET I OSLO
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