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AtropShape focuses on developing new methods for synthesizing atropisomeric molecules, which are important for creating novel pharmaceuticals. The project aims to explore how the unique shapes of these molecules influence their interactions with biological targets, ultimately contributing to drug discovery.
Atropisomeric molecules (atropisomers) are separable conformational isomers arising from restricted rotation around a single bond.
Atropisomers have revolutionized the treatment of several deadly diseases.
The principal goal of AtropShape is to create pharmaceutical leads with unusual conformations and shapes by developing catalytic stereoselective (atroposelective) synthesis methods toward difficult-to-access drug-like atropisomers.
Because atropisomers are chiral, they give rise to two or more…
USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.
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