CORDIS Project
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This project investigates how the bacterium Shigella uses specific proteins to manipulate immune responses during infection. It focuses on the role of ATP release in attracting immune cells and how Shigella's proteins may inhibit this process to evade immune detection.
Shigella invades the intestinal epithelium following injection of type III secretion effectors (T3S) and causes inflammatory, neutrophil-mediated tissue destruction.
The host lab has shown that Shigella invasion induces oscillatory Ca2+-signalling and hemichannel-dependent release of ATP, which is a potent immunostimulatory signal. I propose 1) that ATP release from epithelial cells attracts neutrophils to sites of infection and promotes their activation and 2) that some Shigella T3S effectors…
INSTITUT PASTEUR
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