CORDIS Project
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This project investigates the mechanisms of DNA double-strand break repair, focusing on the MRN complex and its role in activating the DNA damage response. The research aims to clarify how this complex maintains genome stability and its implications for cancer and neurodegenerative disorders.
DNA double-strand breaks are perhaps the most harmful DNA damages and result in carcinogenic chromosome aberrations.
Cells protect their genome by activating a complex signaling and repair network, collectively denoted DNA damage response (DDR). A key initial step of the DDR is the activation of the 360 kDa checkpoint kinase ATM (ataxia telangiectasia mutated) by the multifunctional DSB repair factor Mre11-Rad50-Nbs1 (MRN). MRN senses and tethers DSBs, processes DSBs for further resection, and r…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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