CORDIS Project
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This project investigates the role of macrophage-derived proteoglycans in the development of cardiovascular diseases, particularly atherosclerosis. Using mouse models, it aims to understand how these proteoglycans affect lesion formation and macrophage behavior, potentially identifying new drug targets for treatment.
Cardiovascular diseases (CVD) are the leading cause of death in Western societies. CVD-related deaths are primarily caused by complications of atherosclerosis, a disease initiated via focal infiltration and retention of lipoproteins in the subendothelial matrix of arteries due to a combination of aggregation and interaction with proteoglycans produced by the arteries.
Little is known about the in vivo contribution of macrophage-derived and -associated proteoglycans during atherosclerosis develop…
KATHOLIEKE UNIVERSITEIT LEUVEN
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