CORDIS Project
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This project investigates the role of the CXCL5 chemokine and its receptor CXCR1 in atherosclerosis, focusing on plaque instability and rupture. Using mouse models, it aims to understand the dynamics of leucocyte involvement in cardiovascular disease, potentially leading to new therapeutic targets.
Cardiovascular disease is the main cause of death in Europe and atherosclerosis, a disease of arteries, is the major contributor to this burden.
Leucocytes, which are recruited by chemokines, participate in all disease stages: atheromatous plaque formation, instability, and rupture, the latter one being the cause of acute myocardial infarction.
My findings suggest that the CXCL5 chemokine may play a role in atherosclerosis. I thus propose to investigate the effects of CXCL5 and its receptor CXCR…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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