CORDIS Project
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This project focuses on understanding atherosclerosis by characterizing specific lipid-protein adducts in low-density lipoproteins. Using mass spectrometry, it aims to identify biomarkers for cardiovascular diseases, enhancing early diagnosis and treatment strategies.
Atherosclerosis is a chronic inflammatory response, clinically asymptomatic in the first decade.
The deposition of lipids in arterial walls, due to the uptake of oxidized low density lipoproteins (oxLDL) by macrophages, causes blood flow restriction making cardiovascular diseases (CVD) a serious public health problem in EU countries.
In oxLDL, oxidation of (phospho)lipids and proteins occurs, originating phospholipids-protein adducts by cross-linking reactions.
Though phospholipid-protein adduct…
ASTON UNIVERSITY
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United Kingdom, Glasgow
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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