CORDIS Project
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This project investigates inherited cerebellar ataxia, a group of genetic neurodegenerative diseases affecting coordination. It aims to analyze the signaling pathways and cellular mechanisms in Purkinje neurons using advanced profiling techniques to identify potential therapeutic targets.
Inherited Cerebellar ataxia (CAs) is a large and multifaceted group of rare genetic neurodegenerative diseases affecting mainly the cerebellum and its connection, leading to the loss of coordination and ataxia phenotype.
Purkinje neurons (PN) are crucial cells for cerebellar functionality, but also very sensitive neurons.
Indeed, they were found as the most vulnerable cerebellar neurons in many CAs, both in mouse and human samples.
Although CAs show high genetic heterogeneity and have different…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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Switzerland, LAUSANNE
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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