CORDIS Project
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This project investigates the mechanisms of B cell activation and differentiation, focusing on how antigen polarity influences B cell fate. It aims to enhance understanding of immune responses and their implications for diseases like cancer.
B cell activation required for antibody production and the establishment of immunological memory is initiated by antigen recognition through the B cell receptor (BCR) and subsequent internalization of antigen for presentation to T cells.
After activation, B cells proliferate and differentiate into plasma cells or memory B cells.
The mechanism involved in this B cell fate decision has been recently explored and a new theory has been proposed based on the existence of an asymmetrical B cell divisi…
THE FRANCIS CRICK INSTITUTE LIMITED
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