CORDIS Project
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This project aims to develop a new method for forming carbon-fluorine bonds using cost-effective fluoride salts. The focus is on creating enantiopure fluoroamines for medicinal chemistry, improving drug properties without relying on toxic fluorine gas.
Fluorine is a key element in modern pharmaceutical, agrochemicals and anesthetics.
It is well-known that fluorine substitution can strongly improve drug efficiency by modifying the properties of compounds such as lipophilicity, metabolic stability, bioavailability and protein binding affinity.
The selective installation of fluorine into molecules, especially in a catalytic way, still represents a major challenge for organic synthesis.
To date, chemists have developed a range of transformations f…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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