CORDIS Project
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This project explores the role of astrocytes in Huntington’s disease by developing a mouse model that expresses a mutant form of the huntingtin protein in these cells. It aims to understand how this mutation affects neuronal support functions and contributes to neurodegeneration.
Huntington’s disease (HD) is an inherited neurodegenerative disease, which has no cure, resulting from the mutation of the gene coding for huntingtin protein (htt).
Clinically, HD patients present with progressive involuntary spasmodic movements and cognitive impairments.
Post-mortem studies of HD patients reveal severe atrophy of the striatum, reflecting a selective neuronal loss of medium spiny neurons (MSNs).
The path leading to MSNs death remains unknown.
Conversely, astrocytic dysfunction m…
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