CORDIS Project
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This project investigates the role of microRNAs in regulating gene expression in plants, particularly focusing on their interaction with specific proteins. The research aims to understand the mechanisms of translational repression and its implications for gene silencing.
MicroRNAs (miRNAs) are key post-transcriptional regulators of eukaryotic gene expression.
In plants, most miRNAs associate with AGO1 as part of RNA-induced-silencing-complexes (RISC) to regulate target mRNAs via perfectly or near-perfecly miRNA-complementarity sites.
These sites differ from those found in metazoan miRNA target transcripts, where extensive mis-pairing prevents endonucleolytic cleavage, or ‘slicing’, and favors translational repression as an alternative mode of AGO action.
Recent…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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