CORDIS Project
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The ASTRA project investigates the formation and properties of ribonucleoprotein complexes in neurodegenerative diseases, focusing on how RNA-binding proteins and non-coding RNAs influence these processes. By employing advanced imaging and computational techniques, the project aims to understand RNP dynamics in cells a…
Recent works indicate the pathogenic relevance of altered RNA metabolism and aberrant ribonucleoprotein (RNP) assembly in several neurodegenerative diseases, such as Amyotrophic lateral sclerosis.
How defective RNPs form, what are their integral components and which events trigger their appearance late in life are still unsolved issues.
While emerging evidence indicates that mutations and post-translational modifications of specific RNA-binding proteins (RBPs) induce liquid-solid phase transiti…
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
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