CORDIS Project
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This project investigates the role of small RNA molecules in regulating gene expression in bacteria. It aims to develop artificial small RNAs as tools for studying gene functions and antibiotic resistance, enhancing applications in synthetic biology.
RNA is common to all organisms.
Despite its major function as the coding agent for protein synthesis, an increasing number of regulatory roles have been assigned to RNA.
In bacteria, small RNAs (sRNAs) constitute the best-studied class of non-coding regulators estimated to control ~20% of all genes in a given organism.
Most sRNAs affect gene expression by base-pairing with multiple target mRNAs resulting in either gene repression or activation. sRNA regulators are modular, versatile, and highly…
FRIEDRICH-SCHILLER-UNIVERSITÄT JENA
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