CORDIS Project
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This project seeks to engineer synthetic vesicle transport mechanisms in living cells, focusing on the process of exocytosis. By utilizing DNA-based approaches, it aims to create functional equivalents of natural vesicle machinery to advance genetic medicine.
Imagine being able to design into living cells and organisms de novo vesicle transport mechanisms that do not naturally exist?
At one level this is a wild-eyed notion of synthetic biology.But we contend that this vision can be approached even today, focusing first on the process of exocytosis, a fundamental process that impacts almost every area of physiology.
Enough has now been learned about the natural core machinery (as recognized by the award of the 2013 Nobel Prize in Physiology or Medic…
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