CORDIS Project
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This project evaluates the arrhythmogenic potential of over 250 drugs, including antipsychotics and antihistamines, by combining literature reviews, in-silico modeling, pharmacovigilance data analysis, and cohort studies. The goal is to better predict and rank the risk of QT prolongation and related arrhythmias, enhanc…
The ability of some compounds to prolong the QT interval of the electrocardiogram and to precipitate Torsade de Pointes (TdP, a potentially fatal arrhythmia) has caused several regulatory interventions, including drug withdrawals.
Specific guidelines have been implemented to detect QT liability of new compounds as early as possible.
However there is growing evidence that an increase in the QT interval does not necessarily lead to TdP which further increased the regulatory and clinical difficulti…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
United Kingdom, London
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Italy, Bologna
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Germany, Bremen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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