CORDIS Project
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This project explores the molecular interactions of a protein involved in cholesterol metabolism, focusing on its role in the internalization of low-density lipoprotein. By investigating its structural properties, the research aims to enhance understanding of cardiovascular health.
Hypercholesterolemia, high levels of plasma LDL-cholesterol, is a major risk factor for atherosclerosis and premature coronary heart disease (CHD), the leading cause of death in developed countries.
The clearance of LDL from the circulation occurs via endocytosis with the LDL-receptor (LDLR) mainly by liver cells.
This hepatic recruitment of the LDL-LDLR complex to the clathrin-coated pits is dependent on the endocytic adaptor protein, autosomal recessive hypercholesterolemia (ARH).
Consequently…
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