CORDIS Project
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This project seeks to enhance the understanding of rare genetic variants' impact on complex traits through new computational methods. By reconstructing genealogical relationships and analyzing genetic variation, it aims to improve the detection of associations in genome-wide studies.
Large-scale genome-wide association studies (GWAS) have yielded thousands of genetic as-sociations to heritable traits, but for most common diseases, these signals collectively explain only a small fraction of phenotypic variation.
The phenotypic impact of recent, rare genetic variants, in particular, is poorly understood, but currently available data sets and analytical tools cannot be used to effectively study this class of variation.
To address this problem, we propose to develop new computat…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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