CORDIS Project
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The ARCS project investigates the spread of antibiotic resistance genes in clinical sewage microbiomes. By linking these genes to their microbial hosts, the research aims to enhance understanding of how resistance spreads, which is critical for developing effective treatments against resistant infections.
Antibiotics are essential for treating bacterial infections.
However, antimicrobial resistance (AMR) has spread among pathogenic bacteria, leading to therapy failure or deaths of patients.
Due to their association with promiscuous mobile genetic elements, clinically important antibiotic resistance genes (ARGs) can spread rapidly among diverse bacteria through horizontal gene transfer (HGT).
Due to HGT, identifying the microbial hosts of the ARGs in an ecosystem is a challenge.
Importantly, it ha…
THE UNIVERSITY OF BIRMINGHAM
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