CORDIS Project
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This project focuses on the regulation of aquaporin-2, a water channel in kidneys, which is crucial for urine concentration. It aims to understand the hormonal control of aquaporin-2 shuttling and its implications for water balance disorders.
A proper water balance is essential for life on land and is, besides drinking water, depending on water reabsorption in the kidney.
Renal water uptake depends on the expression of the aquaporin-2 (AQP2) water channel in the urinary membrane of collecting duct cells, which is critically determined by a balance of shuttling of AQP2 to (exocytosis) and from (endocytosis) this membrane.
Humans with insufficient AQP2 levels suffer from Nephrogenic diabetes insipidus (NDI), a disorder in which the kid…
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